Description

Methyl 2,2-Difluoro-3-Oxopentanoate is a versatile fluorinated ketoester building block, prized for its unique reactivity profile in advanced organic synthesis. Its structure, featuring both a difluoro-activated methylene group and a reactive ketoester moiety, makes it a critical intermediate for constructing complex molecules with high precision. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce fluorine atoms and functionalized carbon chains into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and fluorinated materials with unique surface properties.
• Organic Synthesis Building Block: Employed in various name reactions, such as Claisen condensations and Michael additions, to create complex, polyfunctional molecules for research and fine chemical production.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution on reaction pathways and molecular properties in academic and industrial R&D settings.

Basic Information

Product Name	Methyl 2,2-Difluoro-3-Oxopentanoate
CAS No.	196202-01-4
Molecular Formula	C6H8F2O3
Molecular Weight	166.12 g/mol
Synonyms	Methyl 2,2-difluoro-3-oxopentanoate; 2,2-Difluoro-3-oxopentanoic acid methyl ester; Methyl 2,2-difluoro-3-oxovalerate; 3-Oxopentanoic acid, 2,2-difluoro-, methyl ester; Pentanoic acid, 2,2-difluoro-3-oxo-, methyl ester; Methyl difluorolevulinate; Difluorolevulinic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2,2-Difluoro-3-Oxopentanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.