Description

2-Methylphenylboronic Acid, Pinacol Ester is a protected boronic acid derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in its enhanced stability compared to the free boronic acid, making it an ideal reagent for Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those containing biaryl structures via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science Research: Serves as a monomer or building block for creating advanced organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Scale-up: Provides a stable, handleable form of the boronic acid moiety for contract research organizations (CROs) and CDMOs performing multi-step synthesis.

Basic Information

Product Name	2-Methylphenylboronic Acid, Pinacol Ester
CAS No.	195062-59-0
Molecular Formula	C13H19BO2
Molecular Weight	218.10 g/mol
Synonyms	2-Methylbenzeneboronic Acid Pinacol Ester; (2-Methylphenyl)boronic Acid Pinacol Ester; o-Tolylboronic Acid Pinacol Ester; 2-Methylphenylboronic Acid Pinanediol Ester (common alternate); B-(2-Methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(o-tolyl)-1,3,2-dioxaborolane; 2-Tolylboronic Acid Pinacol Ester; CAS 195062-59-0.
EINECS	Contact for details

Quality Control

Our 2-Methylphenylboronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality management system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.