Description

4-Methoxy-3'-Trifluoromethylbiphenyl is a high-purity biphenyl derivative characterized by its methoxy and trifluoromethyl substituents, which confer unique electronic and steric properties. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, valued for its role in modulating the biological activity and physicochemical properties of target molecules. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a core structure for developing new generation herbicides, fungicides, and insecticides, leveraging the stability imparted by the trifluoromethyl group.
• Liquid Crystal & OLED Materials: Used in research and production of advanced electronic display materials due to its biphenyl core and tailored substituents affecting mesomorphic and electroluminescent properties.
• Organic Light-Emitting Diode (OLED) Intermediates: Functions as a building block for host or dopant materials in emissive layers.
• Cross-Coupling Reactions: Acts as a reliable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct more complex biaryl systems.
• Material Science Research: Employed in the development of organic semiconductors, polymers, and metal-organic frameworks (MOFs) with specific electronic characteristics.

Basic Information

Product Name	4-Methoxy-3'-Trifluoromethylbiphenyl
CAS No.	194873-98-8
Molecular Formula	C14H11F3O
Molecular Weight	252.23 g/mol
Synonyms	3'-(Trifluoromethyl)-4-methoxybiphenyl; 4-Methoxy-3'-(trifluoromethyl)biphenyl; 1-Methoxy-4-[3-(trifluoromethyl)phenyl]benzene; [1,1'-Biphenyl]-4-methoxy-3'-(trifluoromethyl)-; 4-Methoxy-3'-trifluoromethyl-1,1'-biphenyl
EINECS	Contact for details

Quality Control

Our 4-Methoxy-3'-Trifluoromethylbiphenyl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and batch-to-batch consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorinating agents. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.