Description

4,5-Difluoroindole-2-Ethylcarboxylate is a high-purity, specialized fluorinated indole derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its unique molecular structure, which is essential for constructing complex molecules with tailored electronic and steric properties. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, drug discovery, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging the fluorine atoms for enhanced bioactivity and metabolic stability.
• Material Science: Serves as a monomer or functional additive in the creation of specialty polymers and advanced organic electronic materials.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in fluorination chemistry and heterocyclic compound synthesis.
• Fluorescent Probe Synthesis: Acts as a core structure for developing sensitive chemical sensors and bio-imaging agents due to the indole fluorophore.

Basic Information

Product Name	4,5-Difluoroindole-2-Ethylcarboxylate
CAS No.	194870-66-1
Molecular Formula	C11H9F2NO2
Molecular Weight	225.19 g/mol
Synonyms	Ethyl 4,5-Difluoro-1H-indole-2-carboxylate; 4,5-Difluoro-1H-indole-2-carboxylic Acid Ethyl Ester; 2-Carbethoxy-4,5-difluoroindole; 4,5-Difluoroindole-2-carboxylic Acid Ethyl Ester; 1H-Indole-2-carboxylic acid, 4,5-difluoro-, ethyl ester; 194870-66-1; 4,5-Difluoro-2-indolecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 4,5-Difluoroindole-2-Ethylcarboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.