Description

3-(4-Bromo-2-Fluoro-3-Methoxy-Phenyl)-3-Oxo-Propionic Acid Ethyl Ester is a high-purity, versatile organic intermediate characterized by its distinct halogenated aromatic structure. This compound is essential for facilitating complex molecular transformations in advanced synthetic chemistry, offering a critical building block for constructing sophisticated active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for their synthesis pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic small molecules.
• Agrochemical Synthesis: Serves as a crucial building block for developing advanced herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Used in the development of organic electronic materials, liquid crystals, and advanced polymers where specific fluorine and bromine substitution patterns are required.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of chemical probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes under cGMP or research-grade conditions.

Basic Information

Product Name	3-(4-Bromo-2-Fluoro-3-Methoxy-Phenyl)-3-Oxo-Propionic Acid Ethyl Ester
CAS No.	194804-99-4
Molecular Formula	C12H12BrFO4
Molecular Weight	319.13 g/mol
Synonyms	Ethyl 3-(4-Bromo-2-fluoro-3-methoxyphenyl)-3-oxopropanoate; 3-Oxo-3-(4-bromo-2-fluoro-3-methoxyphenyl)propionic Acid Ethyl Ester; 4-Bromo-2-fluoro-3-methoxy-β-oxobenzenepropanoic Acid Ethyl Ester; Ethyl (4-Bromo-2-fluoro-3-methoxybenzoyl)acetate; 1-(4-Bromo-2-fluoro-3-methoxyphenyl)-3-ethoxy-1,3-propanedione (enol form); 194804-99-4; AKOS BRN 0867
EINECS	Contact for details

Quality Control

Every batch of 3-(4-Bromo-2-Fluoro-3-Methoxy-Phenyl)-3-Oxo-Propionic Acid Ethyl Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes comprehensive analysis via HPLC, GC, NMR, and MS to meet the stringent requirements of advanced organic synthesis. A Certificate of Analysis (COA) detailing all specification results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.