Description

Thiophene-2-Boronic Acid Pinacol Ester is a high-purity organoboron reagent, specifically a boronic ester derivative of 2-thienylboronic acid. This compound is a critical building block in modern synthetic chemistry, enabling efficient carbon-carbon bond formation via cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality intermediates for constructing complex heterocyclic molecules. Its stability as a pinacol ester offers significant advantages in handling and storage compared to the free boronic acid.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed coupling with aryl or vinyl halides to create biaryl and styryl compounds containing the thiophene moiety.
• Pharmaceutical Intermediate Synthesis: Used in the research and production of active pharmaceutical ingredients (APIs) that incorporate thiophene rings, which are common in various therapeutic agents.
• Agrochemical Development: Serves as a building block for synthesizing novel herbicides, fungicides, and insecticides with thiophene-based structures.
• Organic Electronic Materials: Employed in the synthesis of conjugated polymers and small molecules for applications in organic light-emitting diodes (OLEDs), field-effect transistors (OFETs), and solar cells.
• Ligand and Catalyst Preparation: Useful for creating novel ligands and organometallic catalysts that utilize the thiophene scaffold.
• Chemical Research & Development: A versatile tool for medicinal chemistry, process chemistry, and academic research exploring new synthetic methodologies.

Basic Information

Product Name	Thiophene-2-Boronic Acid Pinacol Ester
CAS No.	193978-23-3
Molecular Formula	C10H15BO2S
Molecular Weight	210.10 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene; 2-Thienylboronic Acid Pinacol Ester; 2-Thiopheneboronic Acid Pinacol Ester; Thiophen-2-ylboronic Acid Pinacol Ester; 2-(Thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol 2-Thienylboronate; 2-Thienyl-Bpin
EINECS	Contact for details

Quality Control

Our Thiophene-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.