Description

(3S)-3-Fmoc-Amino-1-Diazo-4-Methyl-2-Pentanone is a high-purity, non-natural amino acid derivative featuring a diazoketone functional group, making it a versatile building block for advanced organic synthesis. Its core value lies in enabling precise peptide chain elongation and the synthesis of complex, biologically active molecules under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics and novel chemical entities.

Application

• Peptide Synthesis: A key protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS), facilitating the controlled assembly of peptide chains.
• Pharmaceutical Intermediates: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Bioconjugation: Used in the development of antibody-drug conjugates (ADCs) and other targeted drug delivery systems due to its reactive diazo group.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tools for studying enzyme function and protein interactions.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialized polymeric materials with tailored properties.

Basic Information

Product Name	(3S)-3-Fmoc-Amino-1-Diazo-4-Methyl-2-Pentanone
CAS No.	193148-58-2
Molecular Formula	C22H21N3O4
Molecular Weight	391.42 g/mol
Synonyms	Fmoc-Diazo-Leucine; Fmoc-DiazoLeu-OH; (3S)-3-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-1-diazo-4-methylpentan-2-one; 1-Diazo-3-[(9H-fluoren-9-ylmethoxy)carbonyl]amino-4-methyl-2-pentanone; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-diazo-2-oxo-L-norleucine; Fmoc-L-DiazoLeu; Fmoc-Diazo-Leu-OH; Nα-Fmoc-L-diazonorleucine
EINECS	Contact for details

Quality Control

Our (3S)-3-Fmoc-Amino-1-Diazo-4-Methyl-2-Pentanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and decomposition. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.