Description

(R)-n-Fmoc-α-Methyl-2-Fluorophenylalanine, 98% Ee, 98% CAS NO 193086-74-7 is a high-purity, non-natural amino acid derivative featuring a chiral α-methyl group and a 2-fluorophenyl side chain, protected by an Fmoc group. This compound is critical for the synthesis of conformationally constrained peptides and peptidomimetics, enabling advanced research in drug discovery and medicinal chemistry. It is primarily utilized by pharmaceutical R&D laboratories, CROs, and CDMOs focused on developing novel therapeutics, particularly for targeting proteases and protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for introducing steric hindrance and fluorine atoms into peptide sequences.
• Peptidomimetic Drug Discovery: For creating metabolically stable analogs to enhance bioavailability and receptor selectivity.
• Protease Inhibitor Development: Utilized in the design of inhibitors for enzymes like HIV protease or renin, where the α-methyl group prevents proteolytic cleavage.
• Chemical Biology Probes: Incorporation into peptides to study protein function and interactions via 19F NMR spectroscopy.
• Pharmaceutical Intermediate: Serves as a chiral synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: Used in studies exploring novel peptide architectures and their biological activities.

Basic Information

Item	Detail
Product Name	(R)-n-Fmoc-α-Methyl-2-Fluorophenylalanine, 98% Ee, 98%
CAS No.	193086-74-7
Molecular Formula	C26H24FNO4
Molecular Weight	433.47 g/mol
Synonyms	Fmoc-(R)-α-Me-2-F-Phe-OH; (R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(2-fluorophenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-fluorophenyl)-D-alanine; Fmoc-D-α-methyl-2-fluorophenylalanine; (R)-N-Fmoc-α-Methyl-2-fluorophenylalanine; N-α-Fmoc-(R)-2-amino-2-(2-fluorophenyl)propionic acid; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(2-fluorophenyl)propanoic acid
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Every lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm the specified enantiomeric excess (ee) and chemical purity of 98%. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.