Description

Thiamethoxam Impurity 3 is a high-purity chemical reference standard used for analytical and research purposes. This compound is critical for quality control and regulatory compliance in the development and production of the neonicotinoid insecticide Thiamethoxam. It is primarily required by analytical laboratories, agrochemical manufacturers, and regulatory bodies for precise impurity profiling, method validation, and stability studies to ensure product safety and efficacy.

Application

• Analytical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of Thiamethoxam Impurity 3 in active pharmaceutical ingredients (APIs) and technical-grade materials.
• Method Development & Validation: Essential for developing and validating HPLC, UPLC, GC, or LC-MS/MS analytical methods in quality control laboratories.
• Pharmaceutical Impurity Profiling: Serves as a specified impurity in the quality assessment of Thiamethoxam drug substances, supporting regulatory filings (e.g., ICH guidelines).
• Agrochemical Research: Employed in metabolic, environmental fate, and degradation studies of Thiamethoxam to understand its breakdown pathways.
• Stability Testing: Used to monitor the formation of this impurity under various stress conditions (heat, light, humidity) as part of product stability studies.
• Calibration & System Suitability: Acts as a calibration standard to ensure the accuracy and precision of analytical instrumentation.

Basic Information

Product Name	Thiamethoxam Impurity 3
CAS No.	192439-46-6
Molecular Formula	C8H10ClN5O3S
Molecular Weight	291.71 g/mol
Synonyms	3-[(2-Chloro-1,3-thiazol-5-yl)methyl]-5-methyl-1,3,5-oxadiazinan-4-one; Thiamethoxam Impurity C; Thiamethoxam Related Compound C; Thiamethoxam Metabolite C; Thiamethoxam Degradant; CGA 322704 Impurity; (4RS,5RS)-3-[(2-Chloro-1,3-thiazol-5-yl)methyl]-5-methyl-1,3,5-oxadiazinan-4-one
EINECS	Contact for details

Quality Control

Every batch of Thiamethoxam Impurity 3 is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and impurity testing using advanced chromatographic (HPLC, GC) and spectroscopic (NMR, MS) techniques to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results. We support compliance with ICH Q3A/B guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.