Description

1-Methyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is a high-value pharmaceutical intermediate and organic building block featuring a protected boronic acid ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry and materials science. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the efficient synthesis of complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring complex aryl-aryl bond formations.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and bioconjugates for target identification and validation.
• Library Synthesis for Drug Discovery: Enables the rapid construction of diverse compound libraries for high-throughput screening in lead identification programs.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) producing specialized fine chemicals on a commercial scale.

Basic Information

Product Name	1-Methyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea
CAS No.	191171-49-0
Molecular Formula	C14H21BN2O3
Molecular Weight	276.14 g/mol
Synonyms	1-Methyl-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methylphenylurea; Urea, N-methyl-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; [3-[(Methylamino)carbonyl]amino]phenylboronic acid pinacol ester; 3-[(Methylcarbamoyl)amino]phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Methyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent lot-to-lot performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.