Description

1-Methyl-1H-Indole-2-Boronic Acid 2,2-Dimethyl Propane Diol-1,3-Cyclic Ester is a high-purity, protected boronic acid derivative, specifically a pinacol ester, designed for advanced synthetic applications. This compound is a critical building block in modern organic synthesis, offering enhanced stability and handling characteristics compared to its free boronic acid counterpart. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing indole scaffolds.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides requiring specific heterocyclic structures.
• Material Science Research: Serves as a monomer or functional building block for creating organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic research.
• Catalyst Ligand Development: Utilized as a starting material for synthesizing novel ligands used in asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	1-Methyl-1H-Indole-2-Boronic Acid 2,2-Dimethyl Propane Diol-1,3-Cyclic Ester
CAS No.	191162-40-0
Molecular Formula	C16H22BNO2
Molecular Weight	271.17 g/mol
Synonyms	1-Methyl-1H-indol-2-ylboronic acid pinacol ester; 2-(1-Methyl-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-Methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 1-Methylindole-2-boronic acid pinacol ester; N-Methylindole-2-boronic acid pinacol ester; B-(1-Methyl-1H-indol-2-yl)boronic acid pinacol ester; CAS 191162-40-0
EINECS	Contact for details

Quality Control

Our 1-Methyl-1H-Indole-2-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for research and process chemistry. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support our global clientele in pharmaceutical and fine chemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.