Description

Diethyl 2-Chloro-6-Fluorophenyl Malonate is a high-purity fluorinated malonate ester derivative, serving as a critical synthetic intermediate in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the aromatic ring, makes it a versatile building block for constructing complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Fine Chemical & Specialty Polymer Production: Employed in the manufacture of specialty monomers, dyes, and performance chemicals requiring specific halogenated aromatic structures.
• Academic & Contract Research: A valuable reagent for method development and exploratory synthesis in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	Diethyl 2-Chloro-6-Fluorophenyl Malonate
CAS No.	190521-88-1
Molecular Formula	C₁₃H₁₄ClFO₄
Molecular Weight	288.70 g/mol
Synonyms	Diethyl (2-Chloro-6-fluorophenyl)malonate; 2-Chloro-6-fluorophenylmalonic Acid Diethyl Ester; Propanedioic acid, (2-chloro-6-fluorophenyl)-, diethyl ester; Diethyl (2-chloro-6-fluorobenzyl)malonate; Ethyl 2-chloro-6-fluorophenylmalonate; Malonic acid, (2-chloro-6-fluorophenyl)-, diethyl ester; CAS 190521-88-1
EINECS	Contact for details

Quality Control

Our Diethyl 2-Chloro-6-Fluorophenyl Malonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; ensure containers are sealed after use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.