Description

Tetramethylammonium-Trifluoromethanolate is a specialized organofluorine reagent featuring a highly reactive trifluoromethoxide anion paired with a tetramethylammonium cation. This compound is valued for its role as a potent nucleophilic trifluoromethoxylating agent, enabling the efficient introduction of the OCF3 group into organic molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced synthetic applications, including the synthesis of novel fluorinated active ingredients and fine chemicals.

Application

• Nucleophilic Trifluoromethoxylation: A key reagent for the direct introduction of the OCF3 group into aryl, heteroaryl, and alkyl halides via nucleophilic substitution reactions.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of fluorinated drug candidates, where the OCF3 moiety can enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Research: Applied in the synthesis of novel fluorinated pesticides and herbicides, leveraging the unique properties of fluorine to improve efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for synthesizing fluorinated polymers, liquid crystals, or specialty materials with tailored surface properties.
• Methodology Development: A valuable tool in academic and industrial laboratories for developing new synthetic methodologies involving fluorinated alkoxides.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value fluorinated fine chemicals and advanced intermediates.

Basic Information

Product Name	Tetramethylammonium-Trifluoromethanolate
CAS No.	189997-61-3
Molecular Formula	C5H12F3NO
Molecular Weight	159.15 g/mol
Synonyms	Tetramethylammonium Trifluoromethoxide; N,N,N-Trimethylmethanaminium Trifluoromethoxide; Tetramethylammonium Trifluoroethoxide (common misnomer); TMA-TFMO; Trifluoromethoxylate Tetramethylammonium Salt; O-Trifluoromethyl Tetramethylammonium; (Trifluoromethoxy)trimethylammonium
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and high purity, which is critical for sensitive synthetic applications. Each lot is characterized by NMR (1H, 19F) and HPLC analysis to confirm identity and purity. Certificates of Analysis (COA) detailing all test results are available upon request. We adhere to strict in-house quality standards to support research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a recommended temperature of 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (NMR)	Complies
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
19F NMR Purity	Complies

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.