Description

1-Butanone, 2,2-Difluoro-1-Phenyl- (9Ci) is a specialized fluorinated ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring a difluoromethyl ketone moiety adjacent to a phenyl ring, makes it a valuable precursor for introducing fluorinated motifs into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries. It serves as a key intermediate in the development of novel active ingredients where the strategic incorporation of fluorine atoms can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing fluorinated analogs of drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where fluorination improves lipophilicity and environmental persistence.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and coatings with tailored surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the synthesis of novel fluorinated ligands for asymmetric catalysis and organometallic chemistry applications.
• Fluorine Chemistry Studies: A model compound for investigating the reactivity and stability of α,α-difluoroketones under various synthetic conditions.

Basic Information

Product Name	1-Butanone, 2,2-Difluoro-1-Phenyl- (9Ci)
CAS No.	189619-77-0
Molecular Formula	C10H10F2O
Molecular Weight	184.18 g/mol
Synonyms	2,2-Difluoro-1-phenylbutan-1-one; 1-Phenyl-2,2-difluorobutan-1-one; α,α-Difluorobutyrophenone; 2,2-Difluorobutyrophenone; DFBP (abbreviation); NSC 405124; Butyrophenone, 2,2-difluoro-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with customer specifications. We employ advanced analytical techniques including GC, HPLC, NMR, and MS for comprehensive characterization and purity verification. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality management system supports development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.