Description

Benzamide, 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a versatile boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex molecules. It is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and material science sectors for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery pipelines.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific aryl-aryl bond formations.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Employed as a tool compound or linker in the development of biochemical probes and inhibitors.
• Academic & Industrial R&D: Essential reagent for methodological development in synthetic organic chemistry laboratories worldwide.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Benzamide, 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	188665-75-0
Molecular Formula	C13H18BNO3
Molecular Weight	247.10 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-Yl)benzoic acid amide; 2-Borono-benzamide pinacol ester; 2-Carbamoylphenylboronic acid pinacol ester; 2-Aminocarbonylphenylboronic acid pinacol ester; Benzamide, o-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of Benzamide, 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from NMR, HPLC, and other relevant techniques. We adhere to cGMP guidelines where applicable to support our clients in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.