Description

4-Bromo-2,3',4',5'-Tetrafluorobiphenyl is a high-value, multi-fluorinated biphenyl derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its precise halogen and fluorine substitution pattern makes it an essential building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in catalysis, material science, and the synthesis of active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Used to create specialized phosphine or N-heterocyclic carbene (NHC) ligands for transition metal catalysis, including cross-coupling reactions.
• Material Science Research: Serves as a monomer or precursor for synthesizing fluorinated polymers, liquid crystals, and organic electronic materials.
• Chemical Reference Standard: Employed as an analytical standard in quality control and method development for laboratories.
• Academic & Industrial R&D: Fundamental research tool in organic synthesis for studying structure-activity relationships and reaction mechanisms.

Basic Information

Product Name	4-Bromo-2,3',4',5'-Tetrafluorobiphenyl
CAS No.	187804-77-9
Molecular Formula	C12H5BrF4
Molecular Weight	305.07 g/mol
Synonyms	2-Bromo-1,3,4,5-tetrafluoro-4'-phenylbenzene; 1-Bromo-2,3,5,6-tetrafluoro-4-phenylbenzene; [1,1'-Biphenyl]-4-bromo-2,3',4',5'-tetrafluoro-; 4-Bromo-2,3',4',5'-tetrafluoro-1,1'-biphenyl; Biphenyl, 4-bromo-2,3',4',5'-tetrafluoro-
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2,3',4',5'-Tetrafluorobiphenyl is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure consistency and purity for your critical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.