Description

2-(2-Chlorophenyl)-4'-Iodoacetophenone is a specialized halogenated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring both chlorine and iodine substituents on distinct aromatic rings, makes it a versatile precursor for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for structure-activity relationship (SAR) studies.
• Agrochemical Research: Used in the synthesis of experimental herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Acts as a building block for the synthesis of organic electronic materials, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Academic & Institutional Research: Employed in universities and R&D institutes for methodological development and exploratory synthesis in organic chemistry.

Basic Information

Product Name	2-(2-Chlorophenyl)-4'-Iodoacetophenone
CAS No.	187617-06-7
Molecular Formula	C14H10ClIO
Molecular Weight	356.59 g/mol
Synonyms	1-(4-Iodophenyl)-2-(2-chlorophenyl)ethanone; 2-Chloro-2'-(4-iodobenzoyl)biphenyl; 4'-Iodo-2-chlorochalcone; 2-(2-Chlorophenyl)-1-(4-iodophenyl)ethan-1-one; 4-Acetyl-3'-chlorobiphenyl-4'-yl iodide; (4-Iodophenyl)(2-chlorophenyl)methanone (common misnomer); 2-Chloro-α-oxo-4-iodobibenzyl
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Chlorophenyl)-4'-Iodoacetophenone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.