Description

Cyclopropanecarboxaldehyde, 2-[(Trimethylsilyl)Methyl]-, trans- (9Ci) is a specialized organosilicon building block featuring a reactive aldehyde group on a trans-substituted cyclopropane ring. This compound matters for its unique three-dimensional structure and bifunctional reactivity, enabling the synthesis of complex, sterically defined molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced intermediate synthesis and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the cyclopropane moiety can impart specific biological activity and stability.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated chiral ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: Acts as a precursor for functionalized monomers or additives in the development of specialty polymers with tailored properties.
• Academic & R&D Laboratories: Utilized in methodological studies and the exploration of new cyclopropanation or silylation reaction pathways.
• Flavor & Fragrance Chemistry: Investigated as a potential intermediate for creating novel aroma chemicals with unique structural motifs.

Basic Information

Item	Detail
Product Name	Cyclopropanecarboxaldehyde, 2-[(Trimethylsilyl)Methyl]-, trans- (9Ci)
CAS No.	187335-57-5
Molecular Formula	C8H16OSi
Molecular Weight	156.30 g/mol
Synonyms	trans-2-[(Trimethylsilyl)methyl]cyclopropanecarboxaldehyde; (1R,2S)-rel-2-[(Trimethylsilyl)methyl]cyclopropanecarboxaldehyde; 2-((Trimethylsilyl)methyl)cyclopropanecarbaldehyde, trans-; trans-2-(Trimethylsilylmethyl)cyclopropanecarbaldehyde; Cyclopropanecarboxaldehyde, 2-[(trimethylsilyl)methyl]-, (1R,2S)-rel-; (1R,2S)-2-((Trimethylsilyl)methyl)cyclopropane-1-carbaldehyde
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxaldehyde, 2-[(Trimethylsilyl)Methyl]-, trans- (9Ci) is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for advanced intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, and well-ventilated place. Due to its moisture-sensitive and easily oxidized nature, the container should be allowed to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0% (Area %)
Isomeric Purity (trans-)	≥ 98.0% (by GC or NMR)
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.