Description

(R)-Borophe-(+)-Pinanediol CAS NO 186906-12-7 is a high-purity, chiral boronic ester derivative of pinanediol, serving as a crucial chiral auxiliary and building block in asymmetric synthesis. Its primary value lies in enabling the stereoselective formation of carbon-carbon bonds, particularly in Suzuki-Miyaura cross-coupling reactions, which are fundamental to modern pharmaceutical and advanced material development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, enantiomerically pure reagents for constructing complex molecular architectures.

Application

• As a chiral ligand or auxiliary in asymmetric Suzuki-Miyaura cross-coupling reactions for pharmaceutical intermediates.
• Building block for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and agrochemicals.
• Use in the preparation of novel boron-containing compounds for materials science and organic electronics research.
• Key reagent in method development and scale-up processes for stereoselective synthesis in R&D laboratories.
• Intermediate in the synthesis of complex natural products and bioactive molecules requiring specific chirality.
• Potential use in the development of chiral catalysts and organocatalysts.

Basic Information

Product Name	(R)-Borophe-(+)-Pinanediol
CAS No.	186906-12-7
Molecular Formula	C₁₆H₂₁BO₂
Molecular Weight	256.15 g/mol
Synonyms	(R)-(-)-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d][1,3,2]dioxaborole; (R)-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d][1,3,2]dioxaborole; (R)-Boronic acid, B-(2,2-dimethyl-1,3-benzodioxol-4-yl)-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; (R)-Pinanediol phenylboronate; (R)-Borophe-Pinanediol Ester
EINECS	Contact for details

Quality Control

Every batch of (R)-Borophe-(+)-Pinanediol is manufactured under strict quality management protocols to ensure exceptional enantiomeric purity and chemical consistency, critical for sensitive asymmetric synthesis. Our standard grade typically meets a chiral purity of >99% ee, verified by chiral HPLC analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by NMR/HPLC), enantiomeric excess, and impurity profile is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition and maintain optimal reactivity and shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.