Description

(3S)-3-Boc-Amino-1-Diazo-2-Butanone CAS NO 186521-98-2 is a high-purity, chiral diazocarbonyl compound that serves as a versatile building block in advanced organic synthesis. Its value lies in the unique reactivity of the diazo group, enabling precise carbon-carbon and carbon-heteroatom bond formation under mild conditions. This intermediate is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of chiral β-amino acids, peptidomimetics, and other biologically active compounds.
• Asymmetric Synthesis: Employed in metal-catalyzed reactions, such as cyclopropanations and X-H insertions, to construct stereodefined molecular architectures.
• Peptide Chemistry: Used for the site-specific modification and labeling of peptides, leveraging the diazo functionality.
• Agrochemical Research: Building block for developing novel chiral ligands and active ingredients with specific stereochemical requirements.
• Material Science: Intermediate in the creation of specialized polymers and functional materials requiring precise molecular control.
• Academic & Process R&D: Valuable reagent for methodological development and scaling novel synthetic routes in laboratory and pilot-scale settings.

Basic Information

Product Name	(3S)-3-Boc-Amino-1-Diazo-2-Butanone
CAS No.	186521-98-2
Molecular Formula	C9H15N3O3
Molecular Weight	213.24 g/mol
Synonyms	1-Diazo-3-[(1,1-dimethylethoxy)carbonyl]amino]-2-butanone; (3S)-3-[(tert-Butoxycarbonyl)amino]-1-diazo-2-butanone; Boc-D-Ala diazomethyl ketone; tert-Butyl (3S)-3-amino-1-diazo-4-oxobutan-2-ylcarbamate; (S)-3-(Boc-amino)-1-diazo-2-butanone; N-Boc-L-alanine diazomethyl ketone; Diazoketone derivative of Boc-L-alanine
EINECS	Contact for details

Quality Control

Every batch of (3S)-3-Boc-Amino-1-Diazo-2-Butanone is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards suitable for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥95% by HPLC), and chiral integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere for long-term stability. This compound is light-sensitive (store away from light) and should be allowed to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to light brown solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.