Description

1-Propanone, 2-Fluoro-1-(4-Methoxyphenyl)-, (R)- (9Ci) is a chiral fluorinated aromatic ketone, a high-value intermediate prized for its role in asymmetric synthesis and pharmaceutical development. This compound matters for its ability to introduce both fluorine and a specific stereocenter into complex molecular architectures, a critical step in creating bioactive molecules with enhanced metabolic stability and target selectivity. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require enantiomerically pure building blocks for drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Asymmetric Synthesis: Used as a building block in stereoselective reactions, including nucleophilic additions and reductions, to construct complex chiral molecules.
• Agrochemical Research: Serves as a precursor in the synthesis of advanced, enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for use in enantioselective catalysis.
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and materials chemistry.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals and advanced materials requiring specific optical activity.

Basic Information

Item	Detail
Product Name	1-Propanone, 2-Fluoro-1-(4-Methoxyphenyl)-, (R)- (9Ci)
CAS No.	186410-79-7
Molecular Formula	C10H11FO2
Molecular Weight	182.19 g/mol
Synonyms	(R)-2-Fluoro-1-(4-methoxyphenyl)propan-1-one; (R)-2-Fluoro-1-(p-methoxyphenyl)propan-1-one; (R)-α-Fluoro-4-methoxypropiophenone; (R)-1-(4-Methoxyphenyl)-2-fluoropropan-1-one; (R)-p-Methoxy-α-fluoropropiophenone; (R)-FMPP; (R)-Enantiomer of 186410-79-7
EINECS	Contact for details

Quality Control

Our 1-Propanone, 2-Fluoro-1-(4-Methoxyphenyl)-, (R)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization, including chiral HPLC to confirm enantiomeric excess (ee) and standard purity assays. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are provided and available upon request, ensuring full traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.