Description

1,3-Difluoro-4-Nitro-2-(Trimethylsilyl)Benzene is a high-value, multi-functional aromatic building block characterized by its unique combination of fluorine, nitro, and silyl substituents. This compound is critical for advanced organic synthesis, particularly in the development of complex molecules where precise electronic and steric control is required. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and materials science sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of fluorinated drug candidates, including kinase inhibitors and other small-molecule therapeutics where the fluorine atoms enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging the fluorine and nitro groups to fine-tune biological activity and environmental persistence.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials, such as fluorinated polymers or small molecules for OLEDs and semiconductors.
• Cross-Coupling Reactions: The trimethylsilyl group can act as a protective group or be utilized in silicon-based coupling methodologies, while the nitro group is a versatile handle for further functionalization.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis, where the silyl and fluorine substituents modulate steric and electronic properties.

Basic Information

Product Name	1,3-Difluoro-4-Nitro-2-(Trimethylsilyl)Benzene
CAS No.	186315-85-5
Molecular Formula	C9H11F2NO2Si
Molecular Weight	231.27 g/mol
Synonyms	2-(Trimethylsilyl)-1,3-difluoro-4-nitrobenzene; Benzene, 1,3-difluoro-4-nitro-2-(trimethylsilyl)-; 1,3-Difluoro-2-(trimethylsilyl)-4-nitrobenzene; 4-Nitro-1,3-difluoro-2-(trimethylsilyl)benzene; TMS-Difluoronitrobenzene
EINECS	Contact for details

Quality Control

Our 1,3-Difluoro-4-Nitro-2-(Trimethylsilyl)Benzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.