Description

(S)-Amino-(4-Fluoro-Phenyl)-Acetic Acid Hydrochloride is a high-purity, single-enantiomer chiral building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular diseases. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of novel therapeutics and complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially peptidomimetics and enzyme inhibitors.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for APIs with specific stereochemical requirements.
• Asymmetric Synthesis: Employed as a starting material or resolving agent in asymmetric catalytic processes to introduce chirality.
• Peptide Chemistry: Functions as a non-natural amino acid derivative for constructing modified peptide sequences with enhanced stability or activity.
• Bioconjugation & Probe Synthesis: Useful for creating fluorescent or affinity probes for biochemical and diagnostic applications.
• Academic & Industrial Research: Serves as a valuable reagent in medicinal chemistry programs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	(S)-Amino-(4-Fluoro-Phenyl)-Acetic Acid Hydrochloride
CAS No.	185994-15-4
Molecular Formula	C8H9FNO2·HCl
Molecular Weight	203.62 (Free base) / 240.08 (HCl salt)
Synonyms	(S)-2-Amino-2-(4-fluorophenyl)acetic acid hydrochloride; (S)-4-Fluorophenylglycine hydrochloride; (S)-α-Amino-4-fluorobenzeneacetic acid hydrochloride; L-4-Fluorophenylglycine HCl; (S)-F-Phe-OH·HCl; (S)-2-(4-Fluorophenyl)glycine hydrochloride; (S)-4-F-PG-OH·HCl; (S)-Amino(4-fluorophenyl)ethanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Amino-(4-Fluoro-Phenyl)-Acetic Acid Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) documenting identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.