Description

4-Bromo-2-Chloro-1-(Chloromethyl)Benzene is a versatile halogenated benzyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its multi-functional structure, featuring bromo, chloro, and chloromethyl substituents, makes it an essential precursor for constructing complex molecules with high precision. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of receptor modulators and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers and functionalized polymers for specialty materials.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions due to its reactive bromo and chloromethyl groups.
• Chemical Library Development: A valuable scaffold for generating diverse compound libraries in medicinal chemistry and drug discovery programs.

Basic Information

Product Name	4-Bromo-2-Chloro-1-(Chloromethyl)Benzene
CAS No.	185315-49-5
Molecular Formula	C7H5BrCl2
Molecular Weight	239.93 g/mol
Synonyms	1-(Chloromethyl)-4-bromo-2-chlorobenzene; 2-Chloro-4-bromobenzyl Chloride; 4-Bromo-2-chlorobenzyl Chloride; α,4-Dibromo-2-chlorotoluene; Benzene, 4-bromo-2-chloro-1-(chloromethyl)-; (4-Bromo-2-chlorophenyl)methyl chloride; 2-Chloro-α,4-dibromotoluene
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Chloro-1-(Chloromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the results against our stringent internal specifications. We are committed to supplying material that meets the exacting standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.