Description

Methyl 2,4-Difluorobenzoylacetate is a high-purity fluorinated organic building block essential for advanced chemical synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce difluorophenyl motifs into their target structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially those containing difluorobenzene pharmacophores for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluorophenyl group enhances biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with specific electronic or surface properties.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis projects and scale-up services for clients in life sciences.
• Academic and Industrial R&D: Used in research laboratories for methodological development and exploring new chemical reactions involving β-keto esters.

Basic Information

Product Name	Methyl 2,4-Difluorobenzoylacetate
CAS No.	185302-85-6
Molecular Formula	C10H8F2O3
Molecular Weight	214.17 g/mol
Synonyms	Methyl (2,4-difluorobenzoyl)acetate; 3-Oxo-3-(2,4-difluorophenyl)propanoic acid methyl ester; 2,4-Difluorobenzoylacetic acid methyl ester; Methyl 3-(2,4-difluorophenyl)-3-oxopropanoate; Acetic acid, (2,4-difluorobenzoyl)-, methyl ester; Methyl 2,4-difluoro-β-oxobenzenepropanoate; 1-(2,4-Difluorophenyl)-3-methoxy-1,3-propanedione (enol form)
EINECS	Contact for details

Quality Control

Our Methyl 2,4-Difluorobenzoylacetate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP principles where applicable, ensuring reliable consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Typical 99.0%)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.