Description

Acotiamide is a selective acetylcholinesterase inhibitor and muscarinic M1/M2 receptor antagonist developed for the treatment of functional dyspepsia. This compound is a key active pharmaceutical ingredient (API) valued for its prokinetic effects in the upper gastrointestinal tract. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of gastrointestinal therapeutics.

Application

• Primary Active Pharmaceutical Ingredient (API) in prescription medications for functional dyspepsia.
• Reference standard for analytical method development and validation in quality control laboratories.
• Key intermediate in advanced pharmaceutical research and new drug development projects.
• Biochemical research tool for studying gastrointestinal motility and cholinergic pathways.
• Raw material for formulation studies in solid dosage forms such as tablets and capsules.

Basic Information

Product Name	Acotiamide
CAS No.	185106-16-5
Molecular Formula	C21H23N3O4S
Molecular Weight	413.49 g/mol
Synonyms	YM443; Z-338; Acotiamide Hydrochloride Hydrate; N-[2-[Diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]thiazole-4-carboxamide; (4,5-Dimethoxysalicyloyl)-2-[(1-oxoisoindolin-2-yl)methyl]-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our Acotiamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and APIs. A Certificate of Analysis (COA) detailing specific results for assay, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.