Description

trans-4-Chlorocarbonyl-Cyclohexanecarboxylic Acid Methyl Ester is a high-purity, versatile chemical intermediate characterized by its bifunctional reactivity. This compound is essential for the synthesis of complex molecules, offering a strategic combination of an acid chloride and an ester group for sequential or selective transformations. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and advanced materials sectors for constructing novel active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those containing functionalized cyclohexane scaffolds.
• Polymer Chemistry: Used as a monomer or cross-linking agent for producing specialty polyesters, polyamides, and other high-performance polymers.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and plant growth regulators.
• Liquid Crystal & OLED Materials: Employed in the research and production of advanced electronic display components and organic semiconductors.
• Peptide Mimetics & Prodrug Development: Facilitates the creation of peptide analogs and prodrug linkers due to its reactive carbonyl groups.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom chemical synthesis services and scale-up projects.

Basic Information

Product Name	trans-4-Chlorocarbonyl-Cyclohexanecarboxylic Acid Methyl Ester
CAS No.	183996-94-3
Molecular Formula	C9H13ClO3
Molecular Weight	204.65 g/mol
Synonyms	trans-4-(Chlorocarbonyl)cyclohexanecarboxylic acid methyl ester; Methyl trans-4-(chlorocarbonyl)cyclohexanecarboxylate; trans-4-Carbomethoxycyclohexanecarbonyl chloride; (1r,4r)-4-(Methoxycarbonyl)cyclohexanecarbonyl chloride; 4-(Methoxycarbonyl)cyclohexanecarboxylic acid chloride (trans); Cyclohexanecarboxylic acid, 4-(chlorocarbonyl)-, methyl ester, trans-; Methyl 4-(chloroformyl)cyclohexanecarboxylate (trans)
EINECS	Contact for details

Quality Control

Our trans-4-Chlorocarbonyl-Cyclohexanecarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and isomeric consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP and ISO standards for traceability and reliability in your supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isomeric Purity (trans)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.