Description

L-Alanine, 3,3-Difluoro-2-Methyl- (9Ci) is a specialized, non-natural amino acid derivative featuring a difluoromethyl group, which introduces unique steric and electronic properties. This compound is of significant value in medicinal chemistry and agrochemical research as a key building block for the synthesis of novel bioactive molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating fluorinated analogs with enhanced metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of fluorinated drug candidates, particularly in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of advanced, fluorinated pesticides and herbicides to improve efficacy and environmental profile.
• Peptide Mimetics: Incorporated into peptide chains to study structure-activity relationships (SAR) and enhance peptide stability against enzymatic degradation.
• Chemical Biology Probes: Serves as a building block for fluorinated amino acids used in 19F NMR spectroscopy and other biophysical studies.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and cGMP manufacturing of active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: Utilized in universities and research institutes for exploratory synthetic chemistry and material science projects.

Basic Information

Product Name	L-Alanine, 3,3-Difluoro-2-Methyl- (9Ci)
CAS No.	182998-49-8
Molecular Formula	C4H7F2NO2
Molecular Weight	139.10 g/mol
Synonyms	(2S)-2-Amino-3,3-difluoro-2-methylpropanoic acid; L-3,3-Difluoro-2-methylalanine; (S)-2-Amino-3,3-difluoro-2-methylpropanoic acid; 2-Methyl-3,3-difluoro-L-alanine; Alanine, 3,3-difluoro-2-methyl-, L-; 182998-49-8; (S)-3,3-Difluoro-2-methylalanine
EINECS	Contact for details

Quality Control

Our L-Alanine, 3,3-Difluoro-2-Methyl- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.