Description

2H-Cyclopenta[B]Furan-2-One,3,3-Difluorohexahydro-,(3Ar-Cis)-(9Ci) is a high-purity, stereochemically defined fluorinated lactone building block of significant interest in advanced organic synthesis. Its unique cis-fused bicyclic structure and strategically placed fluorine atoms make it a valuable precursor for constructing complex molecular architectures with tailored properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Serves as a building block for creating advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Used in the synthesis of specialty polymers and liquid crystals where the incorporation of fluorine can modify thermal stability, solubility, and electronic properties.
• Fluorine Chemistry & Catalysis: Acts as a model substrate or ligand precursor in studies exploring new fluorination methodologies and asymmetric catalysis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrance molecules, dyes, and other high-value specialty chemicals.

Basic Information

Product Name	2H-Cyclopenta[B]Furan-2-One,3,3-Difluorohexahydro-,(3Ar-Cis)-(9Ci)
CAS No.	182932-06-5
Molecular Formula	C7H8F2O2
Molecular Weight	162.14 g/mol
Synonyms	(3aR,6aS)-3,3-Difluorohexahydro-2H-cyclopenta[b]furan-2-one; cis-3,3-Difluorohexahydro-2H-cyclopenta[b]furan-2-one; 3,3-Difluorohexahydro-2H-cyclopenta[b]furan-2-one, (3aR,6aS)-rel-; 182932-06-5; Fluorinated bicyclic lactone; 3,3-Difluoroperhydrocyclopenta[b]furan-2-one
EINECS	Contact for details

Quality Control

Every batch of our 2H-Cyclopenta[B]Furan-2-One,3,3-Difluorohexahydro-,(3Ar-Cis)-(9Ci) is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and stereochemical integrity. Our standard R&D Grade material is characterized by NMR (¹H, ¹³C, ¹⁹F), HPLC, and GC-MS. Certificates of Analysis (COA) with full spectral data are provided with each shipment, and we support custom synthesis to meet specific purity or isomeric ratio requirements for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Purity (GC)	≥ 97.0% (Area %)
Diastereomeric Ratio (HPLC/NMR)	≥ 95:5 (cis:trans)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.