Description

4-(2-Tetrahydropyranyloxy)Phenylboronic Acid is a versatile and valuable organoboron compound, primarily utilized as a key synthetic intermediate in advanced organic synthesis. Its core value proposition lies in its protected phenol functionality, which provides enhanced stability and selectivity in cross-coupling reactions, a cornerstone of modern pharmaceutical and agrochemical development. This high-purity building block is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing biaryl or phenolic ether structures via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require the incorporation of substituted phenylboronic acid motifs.
• Material Science & OLED Development: Serves as a precursor for creating advanced organic electronic materials, including ligands for metal-organic frameworks (MOFs) and charge-transport layers in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and sensors that leverage boronic acid's affinity for diols, useful in carbohydrate recognition and detection.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry laboratories and for custom synthesis projects in contract research organizations (CROs).
• Liquid Crystal & Polymer Chemistry: Acts as a monomer or intermediate for synthesizing specialty polymers and liquid crystal compounds with specific optical or mechanical properties.

Basic Information

Product Name	4-(2-Tetrahydropyranyloxy)Phenylboronic Acid
CAS No.	182281-01-2
Molecular Formula	C₁₁H₁₅BO₄
Molecular Weight	222.05 g/mol
Synonyms	4-(Tetrahydro-2H-pyran-2-yloxy)benzeneboronic acid; 4-(2-Tetrahydropyranyloxy)benzeneboronic acid; [4-(Oxan-2-yloxy)phenyl]boronic acid; 4-(THP-Oxy)phenylboronic acid; 4-(2H-Pyran-2-yloxy)phenylboronic acid, tetrahydro-; B-[4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenyl]boronic acid; 4-(Tetrahydropyran-2-yloxy)phenylboronic acid
EINECS	Contact for details

Quality Control

Our 4-(2-Tetrahydropyranyloxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with high-purity standards suitable for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.