Description

3',4'-Difluoro-2-Phenylacetophenone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atoms can improve biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorinated structure.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for creating complex biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3',4'-Difluoro-2-Phenylacetophenone
CAS No.	181697-30-3
Molecular Formula	C14H10F2O
Molecular Weight	232.23 g/mol
Synonyms	1-(3,4-Difluorophenyl)-2-phenylethanone; 3,4-Difluoro-2-Phenylacetophenone; 2-Phenyl-1-(3,4-difluorophenyl)ethanone; 1-(3,4-Difluorophenyl)-2-phenylethan-1-one; (3,4-Difluorophenyl)(phenyl)methanone, methylene-; α-Phenyl-3,4-difluoroacetophenone
EINECS	Contact for details

Quality Control

Every batch of 3',4'-Difluoro-2-Phenylacetophenone is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical-grade material meets high-purity requirements for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.