Description

(S)-3-(Amino(Carboxy)Methyl)Bicyclo[1.1.1]Pentane-1-Carboxylicacid is a high-purity, non-natural amino acid derivative featuring the rigid and highly sought-after bicyclo[1.1.1]pentane (BCP) scaffold. This compound is a critical building block for medicinal chemists, enabling the creation of novel drug candidates with improved metabolic stability, enhanced potency, and superior physicochemical profiles. It is primarily utilized in pharmaceutical R&D for the synthesis of peptide mimetics and small molecule therapeutics targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel Active Pharmaceutical Ingredients (APIs), particularly in metabolic disease, oncology, and CNS disorders.
• Peptidomimetic Design: Used to replace traditional amino acids (e.g., phenylalanine, tyrosine) in peptides to confer rigidity, reduce conformational flexibility, and improve proteolytic stability.
• BCP Bioisostere Incorporation: Serves as a source of the BCP moiety, a valuable bioisostere for para-substituted benzene rings or tert-butyl groups, to modulate ADMET properties.
• Chemical Biology Probe Synthesis: Employed in constructing molecular probes for studying protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Potential application in the design of new generation herbicides or fungicides with novel modes of action.
• Material Science: Exploration into functionalized polymers and advanced materials with unique structural properties derived from the BCP core.

Basic Information

Product Name	(S)-3-(Amino(Carboxy)Methyl)Bicyclo[1.1.1]Pentane-1-Carboxylicacid
CAS No.	180465-02-5
Molecular Formula	C9H13NO4
Molecular Weight	199.20 g/mol
Synonyms	(1S)-3-(Aminooxomethyl)bicyclo[1.1.1]pentane-1-acetic acid; (S)-3-(Carbamoylmethyl)bicyclo[1.1.1]pentane-1-carboxylic acid; BCP-Aspartic acid derivative; 1,3-BCP bis-acid amino derivative; (S)-BCP-Asp-OH; 3-(Aminocarbonylmethyl)bicyclo[1.1.1]pentane-1-carboxylic acid, (S)-; (S)-1-(Aminocarbonylmethyl)-3-carboxybicyclo[1.1.1]pentane
EINECS	Contact for details

Quality Control

Our (S)-3-(Amino(Carboxy)Methyl)Bicyclo[1.1.1]Pentane-1-Carboxylicacid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.