Description

2-(4-Amino-2-Chlorophenyl)Acetonitrile is a versatile and high-value aromatic nitrile building block, essential for advanced organic synthesis. Its bifunctional structure, featuring both an amino and a nitrile group on a chlorinated benzene ring, makes it a critical precursor for constructing complex heterocyclic systems and active pharmaceutical ingredients (APIs). This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new molecular entities.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of various heterocyclic compounds, including indoles, quinolines, and benzimidazoles, which are core structures in many drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where its chlorophenyl acetonitrile scaffold provides bioactivity.
• Dye and Pigment Manufacturing: Serves as a precursor for high-performance organic dyes and pigments, particularly azo dyes and complex colorants.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and other functional materials due to its conjugated system.
• Cross-Coupling Reactions: Acts as a valuable substrate in palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig amination for C-C and C-N bond formation.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects and scale-up processes.

Basic Information

Product Name	2-(4-Amino-2-Chlorophenyl)Acetonitrile
CAS No.	180150-18-9
Molecular Formula	C8H7ClN2
Molecular Weight	166.61 g/mol
Synonyms	2-Amino-5-chlorobenzyl cyanide; (4-Amino-2-chlorophenyl)acetonitrile; 4-Amino-2-chlorobenzeneacetonitrile; 2-Chloro-4-aminobenzyl cyanide; 2-Chloro-4-aminophenylacetonitrile; α-Cyano-4-amino-2-chlorotoluene; 4-Amino-α-cyano-2-chlorotoluene
EINECS	Contact for details

Quality Control

Our 2-(4-Amino-2-Chlorophenyl)Acetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.