Description

trans-4-[(Boc-Amino)Methyl]Cyclohexanecarbaldehyde CAS NO 180046-90-6 is a high-purity, protected amino aldehyde building block essential for advanced organic synthesis. This compound is valued for its role as a key chiral intermediate in the construction of complex pharmaceutical molecules and bioactive compounds. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Peptidomimetics Synthesis: Used to introduce constrained cyclohexylalanine analogs and other non-natural amino acid motifs into peptide backbones to enhance stability and bioavailability.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, and plant growth regulators with specific stereochemical requirements.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Useful for creating labeled probes and molecular tools to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring high stereochemical purity and reliable scalability.

Basic Information

Product Name	trans-4-[(Boc-Amino)Methyl]Cyclohexanecarbaldehyde
CAS No.	180046-90-6
Molecular Formula	C₁₃H₂₃NO₃
Molecular Weight	241.33 g/mol
Synonyms	trans-4-[(tert-Butoxycarbonylamino)methyl]cyclohexanecarboxaldehyde; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]methyl]cyclohexanecarboxaldehyde, trans-; (trans-4-Formylcyclohexyl)methyl carbamic acid tert-butyl ester; N-Boc-trans-4-(aminomethyl)cyclohexanecarbaldehyde; Boc-4-Aminomethyl-cyclohexanecarbaldehyde (trans); trans-N-Boc-4-Aminomethylcyclohexanecarboxaldehyde; 180046-90-6; tert-Butyl N-[(trans-4-formylcyclohexyl)methyl]carbamate
EINECS	Contact for details

Quality Control

Our trans-4-[(Boc-Amino)Methyl]Cyclohexanecarbaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and cGMP starting materials. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.