Description

4(3H)-Quinazolinone, 6-(Trifluoromethoxy)- is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethoxy group imparts desirable metabolic stability and lipophilicity. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries focused on creating new molecules with enhanced biological activity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used in developing new-generation herbicides, fungicides, and insecticides where the quinazolinone scaffold offers unique modes of action.
• Chemical Biology Probe: Serves as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a building block for advanced organic electronic materials due to its fused aromatic structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Academic & Institutional Research: Utilized in university and government labs for methodological studies in fluorinated heterocycle chemistry.

Basic Information

Product Name	4(3H)-Quinazolinone, 6-(Trifluoromethoxy)-
CAS No.	179246-09-4
Molecular Formula	C9H5F3N2O2
Molecular Weight	230.15 g/mol
Synonyms	6-(Trifluoromethoxy)quinazolin-4(3H)-one; 6-(Trifluoromethoxy)-4(3H)-quinazolinone; 6-Trifluoromethoxy-4-quinazolinone; 4-Hydroxy-6-(trifluoromethoxy)quinazoline; 6-(Trifluoromethoxy)-3,4-dihydroquinazolin-4-one; Quinazolin-4(3H)-one, 6-(trifluoromethoxy)-; 179246-09-4
EINECS	Contact for details

Quality Control

Our 4(3H)-Quinazolinone, 6-(Trifluoromethoxy)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.