Description

3-[(tert-Butyldimethylsilyl)Oxy]-2-Chloro-6-Fluorobenzaldehyde is a high-value, multi-functional aromatic aldehyde intermediate featuring a protected phenolic hydroxyl group. This compound is specifically engineered to provide chemoselectivity and stability in advanced synthetic pathways, making it a critical building block for complex molecule assembly. It is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro-benzaldehyde scaffold is a common pharmacophore.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers due to its aromatic and electron-withdrawing properties.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-[(tert-Butyldimethylsilyl)Oxy]-2-Chloro-6-Fluorobenzaldehyde
CAS No.	179117-82-9
Molecular Formula	C₁₃H₁₈ClFO₂Si
Molecular Weight	288.82 g/mol
Synonyms	2-Chloro-6-fluoro-3-[(tert-butyldimethylsilyl)oxy]benzaldehyde; 2-Chloro-6-fluoro-3-(tert-butyldimethylsiloxy)benzaldehyde; 3-(tert-Butyldimethylsilyloxy)-2-chloro-6-fluorobenzaldehyde; 2-Chloro-6-fluoro-3-[(1,1-dimethylethyl)dimethylsilyl]oxy]benzaldehyde; 2-Chloro-6-fluoro-3-[(TBDMS)oxy]benzaldehyde; 3-TBDMS-Oxy-2-Chloro-6-Fluorobenzaldehyde; 3-(Tert-Butyldimethylsilyloxy)-2-Chloro-6-Fluorobenzaldehyde
EINECS	Contact for details

Quality Control

Our production of 3-[(tert-Butyldimethylsilyl)Oxy]-2-Chloro-6-Fluorobenzaldehyde adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and impurity profiling. Certificates of Analysis (COA) detailing identity, purity, and all relevant specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.