Description

Cyclopropane, 1-Chloro-1-Ethynyl-2,3-Dimethyl-, (1Alpha,2Beta,3Beta)- (9Ci) is a highly functionalized cyclopropane derivative, serving as a sophisticated and versatile chiral building block in advanced organic synthesis. Its unique structure, featuring a chlorine atom, an ethynyl group, and two methyl groups on a strained three-membered ring, makes it a critical intermediate for constructing complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to introduce the cyclopropane motif—a key pharmacophore known to enhance metabolic stability and modulate biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclopropane ring can improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialized monomers or ligands in the development of advanced polymers and functional materials.
• Asymmetric Catalysis: Employed as a substrate or a ligand precursor in catalytic reactions to study and achieve high enantioselectivity.
• Chemical Biology & Probe Development: Utilized to create molecular probes for studying enzyme mechanisms and biological pathways due to its reactive functional groups.
• Academic & Industrial R&D: A valuable compound for methodological development in organic chemistry, including ring-opening and cross-coupling reactions.

Basic Information

Product Name	Cyclopropane, 1-Chloro-1-Ethynyl-2,3-Dimethyl-, (1Alpha,2Beta,3Beta)- (9Ci)
CAS No.	178899-60-0
Molecular Formula	C7H9Cl
Molecular Weight	128.60 g/mol
Synonyms	(1α,2β,3β)-1-Chloro-1-ethynyl-2,3-dimethylcyclopropane; 1-Chloro-1-ethynyl-2,3-dimethylcyclopropane; (1R,2S,3S)-1-Chloro-1-ethynyl-2,3-dimethylcyclopropane; 1-Chloro-1-ethynyl-cis-2,3-dimethylcyclopropane; Chiral Chloroethynyl Dimethylcyclopropane; 178899-60-0; Cyclopropane, 1-chloro-1-ethynyl-2,3-dimethyl-, (1α,2β,3β)-
EINECS	Contact for details

Quality Control

Every batch of Cyclopropane, 1-Chloro-1-Ethynyl-2,3-Dimethyl-, (1Alpha,2Beta,3Beta)- (9Ci) is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing using advanced analytical techniques (GC, HPLC, NMR) to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed and upright to prevent loss and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Chiral Purity (Chiral GC/HPLC)	≥ 98.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.