Description

(R)-Boroval-(+)-Pinanediol-Hcl is a high-purity, chiral boronic ester derivative used as a critical intermediate in asymmetric synthesis. This compound matters for its role in facilitating stereoselective carbon-carbon bond formation, a cornerstone of modern pharmaceutical and fine chemical manufacturing. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality chiral building blocks.

Application

• Asymmetric Synthesis: Key chiral auxiliary or ligand precursor in Suzuki-Miyaura and other transition-metal catalyzed cross-coupling reactions.
• Pharmaceutical Intermediates: Production of active pharmaceutical ingredients (APIs) requiring specific stereochemistry, particularly in oncology and CNS drug candidates.
• Agrochemical Development: Synthesis of chiral herbicides, fungicides, and pesticides where biological activity is stereospecific.
• Material Science Research: Building block for creating chiral organic frameworks, polymers, and liquid crystals with advanced optical properties.
• Academic & Process R&D: Enabling method development and scale-up studies in academic laboratories and industrial R&D centers.
• Catalyst Development: Serves as a precursor for novel chiral catalysts and ligands used in homogeneous catalysis.

Basic Information

Product Name	(R)-Boroval-(+)-Pinanediol-Hcl
CAS No.	178455-04-4
Molecular Formula	C₁₆H₂₈BClO₂
Molecular Weight	298.66 g/mol
Synonyms	(1R)-(-)-Pinanediol (R)-Borovalinate Hydrochloride; (R)-(-)-2,10-Pinanediol Boronate Ester HCl; (1R,2S,3R,5S)-(-)-Pinanediol (R)-Borovalinate Hydrochloride; (R)-Boronic Acid, Valine Derivative, Pinanediol Ester, Hydrochloride; (R)-α-Amino Boronic Acid Pinanediol Ester HCl; Valineboronic Acid Pinanediol Ester Hydrochloride (R-isomer); BOC-Val-Boronate Pinanediol Ester HCl (related precursor); CAS 178455-04-4
EINECS	Contact for details

Quality Control

Every batch of (R)-Boroval-(+)-Pinanediol-Hcl is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are suitable for use in GMP environments, and we provide comprehensive support for regulatory filings. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.