Description

(R)-Borophe-(+)-Pinanediol-Hcl CAS NO 178455-03-3 is a high-purity, chiral organoboron reagent, specifically the hydrochloride salt of the pinanediol ester of (R)-borophenylalanine. This compound matters as a critical chiral building block and catalyst ligand in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in their synthetic processes.

Application

• As a chiral ligand in transition-metal catalyzed asymmetric reactions, such as Suzuki-Miyaura cross-couplings.
• As a key synthetic intermediate in the preparation of enantiomerically pure active pharmaceutical ingredients (APIs).
• In the research and development of novel boron-containing therapeutics and diagnostic agents.
• For the synthesis of complex natural products and fine chemicals requiring specific stereochemistry.
• In the preparation of chiral catalysts and auxiliaries for use in academic and industrial laboratories.
• As a standard or reference compound in analytical method development for chiral separation techniques (e.g., HPLC, SFC).

Basic Information

Product Name	(R)-Borophe-(+)-Pinanediol-Hcl
CAS No.	178455-03-3
Molecular Formula	C₁₉H₂₈BClNO₄
Molecular Weight	380.69 g/mol
Synonyms	(R)-4-Boronophenylalanine pinanediol ester hydrochloride; (R)-Boc-Phe(Bpin)-OH·HCl (common abbreviation); (R)-Boronophenylalanine pinacol ester hydrochloride (related analog); (2R)-2-Amino-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoic acid pinanediol ester hydrochloride; L-Borophenylalanine pinanediol ester HCl; (R)-BPA pinanediol ester hydrochloride; (R)-F-BPA pinanediol ester HCl
EINECS	Contact for details

Quality Control

Our (R)-Borophe-(+)-Pinanediol-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance and lot-to-lot consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.