Description

2-Butenoic Acid, 4,4,4-Trifluoro-3-Hydroxy-, Methyl Ester is a high-purity fluorinated building block characterized by its unique trifluoromethyl and hydroxy functional groups. This compound is of significant commercial interest for its role in synthesizing advanced molecules with enhanced biological activity and physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in protease inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group improves metabolic stability and lipophilicity.
• Material Science: Serves as a precursor for specialty polymers and coatings, imparting oil- and water-repellent properties.
• Organic Synthesis Building Block: Employed in asymmetric synthesis and medicinal chemistry for introducing chiral, fluorinated segments into complex molecular architectures.
• Liquid Crystal & Electronic Materials: Investigated for use in the synthesis of fluorinated liquid crystals and organic semiconductors.

Basic Information

Product Name	2-Butenoic Acid, 4,4,4-Trifluoro-3-Hydroxy-, Methyl Ester
CAS No.	178380-97-7
Molecular Formula	C6H7F3O3
Molecular Weight	184.11 g/mol
Synonyms	Methyl 4,4,4-Trifluoro-3-hydroxy-2-butenoate; Methyl 3-Hydroxy-4,4,4-trifluorocrotonate; 4,4,4-Trifluoro-3-hydroxybut-2-enoic acid methyl ester; 3-Hydroxy-4,4,4-trifluorocrotonic Acid Methyl Ester; Trifluoromethylhydroxybutenoate Methyl Ester; TFHBM; (Z)-Methyl 4,4,4-trifluoro-3-hydroxybut-2-enoate
EINECS	Contact for details

Quality Control

Our 2-Butenoic Acid, 4,4,4-Trifluoro-3-Hydroxy-, Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.