Description

3',5'-Difluoro-4'-Hydroxypropiophenone is a high-purity fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. Its value lies in its unique molecular structure, which serves as a versatile building block for constructing more complex pharmaceutical and agrochemical active ingredients. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoro and hydroxy groups contribute to biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display applications.
• Organic Light-Emitting Diodes (OLEDs): Acts as a building block for electron-transport or host materials in OLED device fabrication.
• Chemical Research: Employed in academic and industrial laboratories for method development and exploring new fluorination chemistry and cross-coupling reactions.
• Advanced Polymer Modifiers: Used to introduce fluorine and ketone functionalities into polymer chains to alter thermal and surface properties.

Basic Information

Product Name	3',5'-Difluoro-4'-Hydroxypropiophenone
CAS No.	178374-78-2
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	1-(3,5-Difluoro-4-hydroxyphenyl)propan-1-one; 4'-Hydroxy-3',5'-difluoropropiophenone; 3,5-Difluoro-4-hydroxypropiophenone; Propiophenone, 3',5'-difluoro-4'-hydroxy-; 1-(3,5-Difluoro-4-hydroxyphenyl)-1-propanone; DFHP
EINECS	Contact for details

Quality Control

Our 3',5'-Difluoro-4'-Hydroxypropiophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for every shipment, supporting cGMP and ISO standards for traceability and reliability in your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.