Description

A-D-Mannopyranoside, Phenyl 3-o-[(4-Methoxyphenyl)Methyl]-2-o-(Phenylmethyl)-4,6-o-[(R)-Phenylmethylene]-1-Thio- is a sophisticated, multi-protected thioglycoside building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists requiring high-precision glycosylation reactions in the development of complex carbohydrate-based molecules. It is primarily utilized in pharmaceutical R&D for the synthesis of novel glycoconjugates, glycomimetics, and other bioactive compounds where control over stereochemistry and reactivity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex carbohydrate-based active pharmaceutical ingredients (APIs) and prodrugs.
• Glycobiology Research: Used as a protected donor molecule in enzymatic and chemical glycosylation studies to investigate biological recognition processes.
• Glycoconjugate Synthesis: Enables the construction of oligosaccharides, glycolipids, and glycopeptides for vaccine development and diagnostic tools.
• Process Chemistry: Serves as a critical building block in scalable routes for producing glycosylated natural products and novel therapeutics.
• Chemical Biology Probes: Facilitates the creation of labeled or tagged carbohydrate probes for studying enzyme mechanisms and cell-surface interactions.

Basic Information

Product Name	A-D-Mannopyranoside, Phenyl 3-o-[(4-Methoxyphenyl)Methyl]-2-o-(Phenylmethyl)-4,6-o-[(R)-Phenylmethylene]-1-Thio-
CAS No.	177943-74-7
Molecular Formula	C35H36O6S
Molecular Weight	584.73 g/mol
Synonyms	Phenyl 3-O-(4-Methoxybenzyl)-2-O-benzyl-4,6-O-[(R)-benzylidene]-1-thio-α-D-mannopyranoside; 1-Thio-α-D-mannopyranoside derivative; Protected thiomannoside; Glycosyl donor building block; Benzylidene-protected thioglycoside; (R)-Phenylmethylene acetal protected mannoside; 4-Methoxybenzyl (PMB) ether mannose derivative
EINECS	Contact for details

Quality Control

Every batch of this advanced synthetic intermediate is produced and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and MS to ensure structural identity, high chemical purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged manipulation to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.