Description

3'-Chloro-2',6'-Difluoroacetophenone is a high-purity fluorinated acetophenone derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique halogenated aromatic structure, which enables precise molecular modifications essential for developing novel compounds. This intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the difluoro and chloro substituents contribute to biological activity and environmental stability.
• Material Science Research: Employed in the creation of specialty polymers and liquid crystals, where its aromatic core and halogen atoms influence material properties.
• Organic Light-Emitting Diode (OLED) Materials: Acts as a starting material for synthesizing electron-transport or host materials in OLED devices.
• Cross-Coupling Reactions: Serves as a versatile substrate in palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig amination for constructing biaryl systems.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research exploring the effects of fluorine substitution on reactivity and physicochemical properties.

Basic Information

Product Name	3'-Chloro-2',6'-Difluoroacetophenone
CAS No.	177942-50-6
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	1-(3-Chloro-2,6-difluorophenyl)ethanone; 3-Chloro-2,6-difluoroacetophenone; 2',6'-Difluoro-3'-chloroacetophenone; 3-Chloro-2,6-difluoroacetophenone; Ethanone, 1-(3-chloro-2,6-difluorophenyl)-; 3-Chloro-2,6-difluorophenyl methyl ketone; 1-(3-Chloro-2,6-difluorophenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Our 3'-Chloro-2',6'-Difluoroacetophenone is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.