Description

Methyl 3-Amino-2,2-Dimethylpropanoate Hydrochloride is a high-purity, protected amino acid ester derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a sterically hindered, primary amine functionality that is protected in a stable, crystalline hydrochloride salt form, ensuring consistent reactivity and simplified handling. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and complex specialty molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, especially those requiring sterically constrained amino acid motifs.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to incorporate the 3-amino-2,2-dimethylpropanoate moiety into peptide backbones to enhance metabolic stability and modify biological activity.
• Agrochemical Research: Employed as a building block for developing novel herbicides, fungicides, and plant growth regulators with tailored properties.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer & Material Science: Acts as a monomer or functionalizing agent for creating specialty polymers with amine functionality.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	Methyl 3-Amino-2,2-Dimethylpropanoate Hydrochloride
CAS No.	177269-37-3
Molecular Formula	C7H16ClNO2
Molecular Weight	181.66 g/mol
Synonyms	3-Amino-2,2-dimethylpropanoic acid methyl ester hydrochloride; Methyl 3-amino-2,2-dimethylpropionate hydrochloride; Methyl β-aminoisobutyrate hydrochloride; 3-Amino-2,2-dimethyl-methylpropionate HCl; 2,2-Dimethyl-3-aminopropionic acid methyl ester hydrochloride; Methyl 3-amino-2,2-dimethylpropanoate HCl; 3-Amino-2,2-dimethylpropionic acid methyl ester hydrochloride; Meldrum's acid derivative amine ester hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 3-Amino-2,2-Dimethylpropanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via IR and NMR spectroscopy, and stringent control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.