Description

4'-Chloro-2'-Fluoro-5'-Methylacetophenone is a high-purity, multi-functional aromatic ketone building block essential for advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and complex agrochemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the chloro-fluoro-methyl substitution pattern enhances biological activity and selectivity.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating complex organic molecules used in electronic display technologies.
• Organic Synthesis Reagent: Employed in Friedel-Crafts acylation and subsequent functional group transformations to create diverse chemical libraries.
• Chemical Research & Development: Utilized in academic and industrial R&D for exploring new reaction pathways and synthesizing complex heterocyclic compounds.

Basic Information

Product Name	4'-Chloro-2'-Fluoro-5'-Methylacetophenone
CAS No.	177211-26-6
Molecular Formula	C9H8ClFO
Molecular Weight	186.61 g/mol
Synonyms	1-(4-Chloro-2-fluoro-5-methylphenyl)ethanone; 1-(4-Chloro-2-fluoro-5-methylphenyl)ethan-1-one; 4-Chloro-2-fluoro-5-methylacetophenone; 2-Fluoro-4-chloro-5-methylacetophenone; 5-Methyl-4-chloro-2-fluoroacetophenone; p-Chloro-o-fluoro-m-methylacetophenone; Acetophenone, 4'-chloro-2'-fluoro-5'-methyl-
EINECS	Contact for details

Quality Control

Our 4'-Chloro-2'-Fluoro-5'-Methylacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.