Description

3-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Benzoic Acid is a specialized photoaffinity labeling reagent featuring a reactive diazirine group and a benzoic acid handle. This compound matters for its ability to form covalent bonds with target biomolecules upon UV light activation, making it indispensable for studying protein-protein interactions, ligand binding sites, and molecular mapping. It is primarily needed by researchers and manufacturers in pharmaceutical R&D, chemical biology, and proteomics for developing novel therapeutics and diagnostic tools.

Application

• Photoaffinity Labeling (PAL): A critical tool in chemical biology for covalently "capturing" transient or weak interactions between small molecules and their protein targets upon photolysis.
• Proteomics Research: Used to identify and characterize unknown protein binding sites, aiding in drug discovery and understanding disease mechanisms.
• Bioconjugation & Probe Synthesis: The carboxylic acid functional group allows for conjugation to amines, alcohols, or other molecules via standard coupling chemistry to create customized molecular probes.
• Structural Biology Studies: Employed to "freeze" dynamic complexes for analysis by techniques like mass spectrometry or X-ray crystallography.
• Material Science Surface Modification: Can be used to functionalize surfaces with photoreactive groups for creating bioactive interfaces or sensors.

Basic Information

Product Name	3-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Benzoic Acid
CAS No.	176389-60-9
Molecular Formula	C9H5F3N2O2
Molecular Weight	230.15 g/mol
Synonyms	3-[3-(Trifluoromethyl)diazirin-3-yl]benzoic acid; 3-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzoic acid; Benzoic acid, 3-[3-(trifluoromethyl)-3H-diazirin-3-yl]-; 3-(3-Trifluoromethyl-3H-diazirin-3-yl)benzoic Acid; TFD Benzoic Acid; Photoaffinity Labeling Reagent 176389-60-9; 3-(3-Trifluoromethyl-diazirin-3-yl)-benzoic acid
EINECS	Contact for details

Quality Control

Our 3-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Benzoic Acid is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability parameters. We adhere to ISO 9001 quality management standards, and our processes are designed to meet the rigorous demands of pharmaceutical and analytical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is strictly light-sensitive and hygroscopic; it must be protected from all light exposure and moisture. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.