Description

8,8-Difluoro-1,4-Dioxaspiro[4.5]Decane is a high-value fluorinated spirocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring a protected 1,4-cyclohexanedione core with two fluorine atoms at a key position, makes it a versatile precursor for introducing difluoromethylene groups into complex molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethylene unit can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a building block for specialty polymers and advanced materials requiring fluorinated segments for specific chemical resistance or surface properties.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex, fluorinated heterocycles and spirocyclic compounds via ring-opening and functionalization reactions.
• Fluorine Chemistry Research: An important substrate for studying the reactivity and incorporation of gem-difluoro motifs, which are valuable bioisosteres for carbonyl and methylene groups.

Basic Information

Product Name	8,8-Difluoro-1,4-Dioxaspiro[4.5]Decane
CAS No.	176251-49-3
Molecular Formula	C9H12F2O2
Molecular Weight	190.19 g/mol
Synonyms	1,4-Dioxaspiro[4.5]decane, 8,8-difluoro-; 8,8-Difluoro-1,4-dioxaspiro[4.5]decane; 2,2-Difluoro-1,4-cyclohexanedione ethylene ketal; 2,2-Difluoro-1,4-cyclohexanedione cyclic ethylene ketal; 1,4-Cyclohexanedione, 2,2-difluoro-, ethylene ketal; Difluoro Spiro Ketal; 8,8-Difluoro-1,4-dioxaspiro[4,5]decane
EINECS	Contact for details

Quality Control

Our 8,8-Difluoro-1,4-Dioxaspiro[4.5]Decane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity and impurity profiles. Our quality commitment aligns with the standards required for cGMP starting material applications and REACH compliance for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids/bases and oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.