Description

Cyclobutanecarboxaldehyde, 2-Phenyl-, trans- (9Ci) CAS NO 176172-03-5 is a specialized chiral aldehyde building block featuring a trans-substituted cyclobutane ring. This compound is valued for its rigid, strained structure which imparts unique stereoelectronic properties, making it a critical intermediate in advanced organic synthesis. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the development of novel active ingredients and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where its stereochemistry can influence biological activity and selectivity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in stereoselective transformations.
• Material Science: Investigated as a monomer or cross-linking agent for producing polymers with specific thermal and mechanical properties.
• Flavor & Fragrance Chemistry: Potential intermediate for creating complex, stereodefined aroma chemicals.
• Academic & Process Chemistry: Employed in methodological studies and scale-up process development for complex organic molecules.

Basic Information

Product Name	Cyclobutanecarboxaldehyde, 2-Phenyl-, trans- (9Ci)
CAS No.	176172-03-5
Molecular Formula	C11H12O
Molecular Weight	160.21 g/mol
Synonyms	trans-2-Phenylcyclobutanecarboxaldehyde; (1R,2S)-2-Phenylcyclobutanecarbaldehyde; (1S,2R)-2-Phenylcyclobutanecarbaldehyde; 2-Phenylcyclobutanecarboxaldehyde, trans-; trans-2-Phenylcyclobutanecarbaldehyde; (trans)-2-Phenylcyclobutanecarboxaldehyde; Cyclobutanecarboxaldehyde, 2-phenyl-, trans-; 2-Phenylcyclobutanecarbaldehyde (trans isomer)
EINECS	Contact for details

Quality Control

Every batch of trans-2-Phenylcyclobutanecarboxaldehyde is produced and tested under strict quality management protocols to ensure high chemical purity and enantiomeric excess. Our products undergo rigorous quality testing, including chiral HPLC analysis, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing purity, chiral purity, and identity are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.