Description

2-[3,5-Bis(Trifluoromethyl)Benzoyl]Benzoic Acid is a high-value, multi-functional aromatic carboxylic acid derivative characterized by its electron-deficient trifluoromethyl-substituted benzoyl moiety. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, prized for its ability to impart unique physicochemical properties to target molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl groups enhance biological activity and environmental stability.
• Ligand & Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors for OLEDs, due to its electron-accepting properties.
• Custom Synthesis & Contract Manufacturing: A crucial starting material for custom synthesis projects and scale-up production under cGMP conditions.
• Chemical Research & Development: Fundamental reagent for exploring new organic reactions and constructing complex polyfunctional aromatic systems in academic and industrial labs.

Basic Information

Product Name	2-[3,5-Bis(Trifluoromethyl)Benzoyl]Benzoic Acid
CAS No.	175278-06-5
Molecular Formula	C17H8F6O3
Molecular Weight	374.24 g/mol
Synonyms	2-[3,5-Bis(trifluoromethyl)benzoyl]benzoic acid; 2-(3,5-Bis(trifluoromethyl)benzoyl)benzoic acid; Benzoic acid, 2-[3,5-bis(trifluoromethyl)benzoyl]-; α-Oxo-3,5-bis(trifluoromethyl)benzenepropanoic acid; 2-(3,5-Di(trifluoromethyl)benzoyl)benzoic acid; 2-(3,5-Bis(trifluoromethyl)benzoyl)benzoic acid; 175278-06-5; 2-(3,5-Bis(trifluoromethyl)benzoyl)benzoic acid
EINECS	Contact for details

Quality Control

Our production of 2-[3,5-Bis(Trifluoromethyl)Benzoyl]Benzoic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure consistent high purity and batch-to-batch reproducibility. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material manufactured under controlled GMP-like conditions for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.