Description

1-Iodo-2-(Trifluoromethoxy)Benzene is a high-value, multi-functional fluorinated aromatic building block. This compound matters for its unique combination of an iodine substituent, which offers excellent reactivity for cross-coupling reactions, and a stable trifluoromethoxy group, which imparts desirable physicochemical properties. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the trifluoromethoxy pharmacophore.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides where the fluorine content enhances biological activity and environmental stability.
• Material Science: Serves as a precursor for liquid crystals, organic semiconductors, and other specialty polymers requiring halogenated aromatic units.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for Suzuki, Stille, and Sonogashira couplings to construct complex biaryl structures.
• Chemical Research: Employed in academic and industrial R&D for exploring new fluorination methodologies and reaction pathways.
• Ligand Preparation: Useful for synthesizing specialized ligands used in catalysis and coordination chemistry.

Basic Information

Product Name	1-Iodo-2-(Trifluoromethoxy)Benzene
CAS No.	175278-00-9
Molecular Formula	C7H4F3IO
Molecular Weight	287.01 g/mol
Synonyms	2-(Trifluoromethoxy)iodobenzene; o-Iodo(trifluoromethoxy)benzene; 1-Iodo-2-(trifluoromethoxy)benzene; 2-Iodo-1-(trifluoromethoxy)benzene; Benzene, 1-iodo-2-(trifluoromethoxy)-; Iodobenzene, 2-(trifluoromethoxy)-; α,α,α-Trifluoro-o-iodoanisole
EINECS	Contact for details

Quality Control

Our 1-Iodo-2-(Trifluoromethoxy)Benzene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry and inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.